MovDisordV3, Main, Exploration, bibRecord, 003A17

Apolipoprotein E ϵ4 and catechol‐O‐methyltransferase alleles in autopsy‐proven Parkinson's disease: Relationship to dementia and hallucinations

Identifieur interne : 003A17 ( Main/Exploration ); précédent : 003A16; suivant : 003A18

Apolipoprotein E ϵ4 and catechol‐O‐methyltransferase alleles in autopsy‐proven Parkinson's disease: Relationship to dementia and hallucinations

Auteurs : Richard Camicioli [Canada] ; Ali Rajput [Canada] ; Michelle Rajput [Canada] ; Christian Reece [Canada] ; Haydeh Payami [États-Unis] ; Chunhai Hao [Canada] ; Alex Rajput [Canada]

Source :

Movement Disorders [ 0885-3185 ] ; 2005-08.

RBID : ISTEX:18A0ACE65619AB988E7D837613A1DD2EB1E0A74C

Descripteurs français

Pascal (Inist)
- Apolipoprotéine E, Autopsie, Catechol O-methyltransferase, Démence, Hallucination, Parkinson maladie, Système nerveux pathologie.

English descriptors

KwdEn :
- Age of Onset, Aged, Aged, 80 and over, Apolipoprotein E, Apolipoprotein E4, Apolipoproteins E (genetics), Autopsy, Autopsy (methods), Catechol O-Methyltransferase (genetics), Catechol O-methyltransferase, Cerebral Cortex (pathology), Dementia, Dementia (complications), Dementia (genetics), Dementia (pathology), Demography, Female, Gene Frequency, Genotype, Hallucination, Hallucinations (complications), Hallucinations (genetics), Hallucinations (pathology), Humans, Lewy Bodies (pathology), Male, Nervous system diseases, Parkinson Disease (complications), Parkinson Disease (genetics), Parkinson Disease (pathology), Parkinson disease, Parkinson's disease, Postmortem Changes, Prospective Studies, Regression Analysis, catechol‐O‐methyltransferase, dementia, hallucinations.
MESH :
- chemical , genetics : Apolipoproteins E, Catechol O-Methyltransferase.
- chemical : Apolipoprotein E4.
- complications : Dementia, Hallucinations, Parkinson Disease.
- genetics : Dementia, Hallucinations, Parkinson Disease.
- methods : Autopsy.
- pathology : Cerebral Cortex, Dementia, Hallucinations, Lewy Bodies, Parkinson Disease.
- Age of Onset, Aged, Aged, 80 and over, Demography, Female, Gene Frequency, Genotype, Humans, Male, Postmortem Changes, Prospective Studies, Regression Analysis.

Abstract

We determined whether apolipoprotein E ϵ4 (ApoE4) or catechol‐O‐methyltransferase (COMT) genotypes were associated with dementia, hallucinations, Alzheimer's disease pathological findings (AP), or cortical Lewy bodies (CLBs) in autopsy‐confirmed cases of Parkinson's disease (PD). Outcomes were obtained from medical records. Pathology reports identified AP and CLBs. Brain tissue was genotyped. A total of 47 subjects (33 men, 14 women) had PD onset at 62.4 ± 8.7 years of age and died at 77.8 ± 5.6 years of age. Demented and hallucinating patients did not differ in age at onset (AO) of PD or age at death, or the proportion ApoE4+, AP+, or CLB+ compared to nondemented patients or nonhallucinating patients. ApoE4 and COMT (low metabolizer [LH], intermediate metabolizer [HL], or high metabolizer [HH]) did not influence AO, death, or dementia‐ or hallucination‐free survival, based on age or duration of treatment. All seven subjects with AP were demented and had hallucinations. CLBs were associated with dementia but not hallucinations. In Cox regression models adjusting for AO and duration of treatment, increased risk of dementia was associated with male sex but not significantly with ApoE4; inclusion of AP in the model did not affect the results; COMT was not a risk factor for dementia. Psychosis risk was not associated with ApoE4, COMT, or sex. The observation that males have increased dementia risk and the trend for ApoE4 requires confirmation in larger prospective autopsy studies. © 2005 Movement Disorder Society

Url:

https://api.istex.fr/document/18A0ACE65619AB988E7D837613A1DD2EB1E0A74C/fulltext/pdf

DOI: 10.1002/mds.20481

Affiliations:

Le document en format XML

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<term>Aged, 80 and over</term>
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<term>Apolipoprotein E4</term>
<term>Apolipoproteins E (genetics)</term>
<term>Autopsy</term>
<term>Autopsy (methods)</term>
<term>Catechol O-Methyltransferase (genetics)</term>
<term>Catechol O-methyltransferase</term>
<term>Cerebral Cortex (pathology)</term>
<term>Dementia</term>
<term>Dementia (complications)</term>
<term>Dementia (genetics)</term>
<term>Dementia (pathology)</term>
<term>Demography</term>
<term>Female</term>
<term>Gene Frequency</term>
<term>Genotype</term>
<term>Hallucination</term>
<term>Hallucinations (complications)</term>
<term>Hallucinations (genetics)</term>
<term>Hallucinations (pathology)</term>
<term>Humans</term>
<term>Lewy Bodies (pathology)</term>
<term>Male</term>
<term>Nervous system diseases</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (genetics)</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinson disease</term>
<term>Parkinson's disease</term>
<term>Postmortem Changes</term>
<term>Prospective Studies</term>
<term>Regression Analysis</term>
<term>catechol‐O‐methyltransferase</term>
<term>dementia</term>
<term>hallucinations</term>
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<term>Hallucinations</term>
<term>Parkinson Disease</term>
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<term>Dementia</term>
<term>Hallucinations</term>
<term>Lewy Bodies</term>
<term>Parkinson Disease</term>
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<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Demography</term>
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<term>Gene Frequency</term>
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<term>Postmortem Changes</term>
<term>Prospective Studies</term>
<term>Regression Analysis</term>
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<term>Démence</term>
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<front><div type="abstract" xml:lang="en">We determined whether apolipoprotein E ϵ4 (ApoE4) or catechol‐O‐methyltransferase (COMT) genotypes were associated with dementia, hallucinations, Alzheimer's disease pathological findings (AP), or cortical Lewy bodies (CLBs) in autopsy‐confirmed cases of Parkinson's disease (PD). Outcomes were obtained from medical records. Pathology reports identified AP and CLBs. Brain tissue was genotyped. A total of 47 subjects (33 men, 14 women) had PD onset at 62.4 ± 8.7 years of age and died at 77.8 ± 5.6 years of age. Demented and hallucinating patients did not differ in age at onset (AO) of PD or age at death, or the proportion ApoE4+, AP+, or CLB+ compared to nondemented patients or nonhallucinating patients. ApoE4 and COMT (low metabolizer [LH], intermediate metabolizer [HL], or high metabolizer [HH]) did not influence AO, death, or dementia‐ or hallucination‐free survival, based on age or duration of treatment. All seven subjects with AP were demented and had hallucinations. CLBs were associated with dementia but not hallucinations. In Cox regression models adjusting for AO and duration of treatment, increased risk of dementia was associated with male sex but not significantly with ApoE4; inclusion of AP in the model did not affect the results; COMT was not a risk factor for dementia. Psychosis risk was not associated with ApoE4, COMT, or sex. The observation that males have increased dementia risk and the trend for ApoE4 requires confirmation in larger prospective autopsy studies. © 2005 Movement Disorder Society</div>
</front>
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Movement Disorders (revue)

Apolipoprotein E ϵ4 and catechol‐O‐methyltransferase alleles in autopsy‐proven Parkinson's disease: Relationship to dementia and hallucinations

Apolipoprotein E ϵ4 and catechol‐O‐methyltransferase alleles in autopsy‐proven Parkinson's disease: Relationship to dementia and hallucinations

Source :

Descripteurs français

English descriptors

Abstract

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	Movement Disorders (revue)
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